Wash the contaminated area with soap and water sufficiently. Cellulose, 2hydroxypropyl ether product safety read and understand the material safety data sheet msds before using this product. Our team of scientists has experience in all areas of research including life science, material science, chemical synthesis, chromatography, analytical and many others. Details of the supplier of the safety data sheet 2. Hydroxy propyl methyl cellulose cas no 9004653 material. The product meets the monograph requirements of the national formulary nf, european pharmacopoeia ep, and japanese pharmacopoeia jp. The toxicological properties of this material have not been fully investigated. Add 10 ml of chromium trioxide solution 30 g in 70 ml. It combines organic solvent solubility, thermoplasticity, and surface activity with the aqueous thickening and stabilizing properties characteristic of other watersoluble cellulose polymers available from ashland. Safety data sheet hydroxypropyl methylcellulose date prepared.
This product does not contain any chemicals known to state of california to cause cancer, birth defects, or any other reproductive harm. Material safety data sheet hydroxypropyl cellulose average. Wear appropriate protective eyeglasses or chemical safety goggles as described by oshas eye and face protection regulations in 29 cfr 1910. Ginshicel mh product information methyl hydroxypropyl cellulose cas number. List of abbreviations and acronyms that could be, but not necessarily are, used in this safety data sheet. Safety data sheet sds applies only to the material as packaged. Pfizer inc believes that the information contained in this material safety data sheet is accurate, and while it. In this study, we explored the incorporation of hydroxypropyl cellulose hpc into a cnc film prepared by slow evaporation. Hydroxypropyl cellulose is a derivative of cellulose. Hydroxypropyl cellulose average mw 370,000, powder, 20 mesh particle size 99% through. This msds has been prepared by deep south chemical, inc. Hazards identification classification of the substance or mixture ghs classification not classified as hazardous. Proprietary ingredients indicated as hazardous have been assessed under standards for workplace safety. Hydroxypropyl cellulose an overview sciencedirect topics.
Material safety data sheet hydroxypropyl cellulose average mol. It is used in the industry as an excipient and as an ophthalmic ingredient to treat dry eye disease and irritation caused by insufficient tears. Methocel k100m premium hydroxypropyl methylcellulose. Its semisynthetic in that it begins as cellulose, the carbohydrate building block of plant fiber. Iridescent cellulose nanocrystal films modified with. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. To support new drug applications in the united states, drug master files dmfs for these products are on file at the bureau of drugs of the u. Used as a emulsifier, stabilizer, whipping aid, protective colloid, film former or thickener in foods.
Chemicalbook provide chemical industry users with hydroxypropyl cellulose boiling point melting point,hydroxypropyl cellulose density msds formula use. Propylene glycol ether of methylcellulose modified cellulose. Klucel hydroxypropylcellulose hpc physical and chemical. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Hpmc is hydrophilic water soluble, a biodegradable, and biocompatible polymer having a wide range of applications in drug delivery, dyes and paints, cosmetics, adhesives, coatings. Hydroxypropylmethyl cellulose viscosity 2,6005,600 cp. Chemistry of methocel cellulose ethers 1 the former official monograph name of hypromellose was hydroxypropyl methylcellulose or hpmc. Identification 1 product identifier product name lhpc grade name lh11, lh21, lh22, lh31, lh32, lhb1 compendial name lowsubstituted hydroxypropyl cellulose nf substance name lowsubstituted hydroxypropyl cellulose 2 suppliers detail suppliers name shinetsu chemical co. Hydroxypropyl cellulose 9004642 not listed lactose monohydrate 64044515 not listed propylene glycol 57556 2003380. Use of super fine grade hydroxypropyl cellulosehpcssl sfp in dry manufacturing. American polymer standards corporation safety data sheet page 2 of 5 hydroxypropyl methylcellulose section 5. Stage 6 harmonization official december 1, 2014 hydroxypropyl1. Artificial tears may also be used for hypromeloose not listed in this medication guide. Safety data sheet hydroxypropyl cellulose average mw.
Common name hydroxypropyl methylcellulose chemical name cellulose, 2hydroxypropyl methyl ether chemical structure cas number 9004653 proportion range more than 95% 4. Hydroxypropyl cellulose 9004642 tci america tci chemicals. Clear up spills immediately and dispose of waste safely. Firefighting measures suitable extinguishing media.
Hydroxypropyl cellulose 9004642 not listed not listed povidone 9003398 not listed not listed purified water 7732185 2317912 not listed additional information. Safety assessment of hydroxypropyl methylcellulose as a food. A wide variety of hydroxypropyl cellulose price options are available to you, there are 742 suppliers who sells hydroxypropyl cellulose price on, mainly located in asia. Hypromellose msds pdf samples general properties of methocel cellulose ethers general properties common to the whole family of methocel cellulose ether products are listed below. Safety data sheet hydroxypropyl cellulose average mw 50,000 1250,000 according to regulation ec no 19072006, annex ii, as amended. The interaction of sodium dodecylsulfate with hydroxypropyl. General properties of methocel cellulose ethers general properties common to the whole family of methocel cellulose ether products are listed below.
Safety data sheet hydroxypropyl cellulose average mw 50,000. The average number of substituted hydroxyl groups per glucose unit is referred to as the degree of substitution ds. Therefore, take proper measures like informing the people in the. However, its gelling temperature in hot water is significantly higher than that of methyl cellulose mc. The propylene oxide can be substituted on the cellulose through an ether linkage at the three reactive hydroxyls present on each anhydroglucose monomer unit of the cellulose chain. Section 12 ecological information section disposal considerations dispose of in a manner. Cellulose hydroxypropyl methyl ether methocel 20231 hydroxypropyl methylcellulose culminal mhpc. Identification of the substancemixture and of the companyundertaking 1. Remove person to fresh air and get medical attention skin contact. Show this safety data sheet to the doctor in attendance. The information in this msds is written in good faith, but. Use dry chemical powder, water spray fog, foam or co2. An idealized structure for a portion of a hydroxypropyl cellulose molecule with a molar substitution ms of 3.
Hydroxypropyl methylcellulose, also known as hypropmellose or e464, is a semisynthetic form of cellulose used to make gel caps. Nlt 2 between isopropyl iodide and low the water to evaporate. In cosmetic and personal care product formulations it is used as a binder, emulsion stabilizer, film former, and a vis. Chemical name cellulose, 2 hydroxypropyl methyl ether.
Hydroxypropyl cellulose average mw 370,000, powder, 20. Hydroxypropyl methyl cellulose is easily soluble in cold water but difficult to be soluble in hot water. Hydroxypropyl cellulose sc252897 hazard alert code key. Section 12 ecological information section disposal considerations dispose of in a manner consistent with federal, state, and local regulations. Should you have any questions about the hydroxypropyl cellulose monograph, please contact dr. Use water spray, alcoholresistant foam, dry chemical, or carbon dioxide. Microcrystalline cellulose 9004346 2326749 not listed ingredient cas number eu einecselincs list ghs classification % hydrogenated castor oil 8001783 2322922 not listed hydroxypropyl methylcellulose 9004653 not listed not listed sodium starch glycolate 9063381 not listed not listed additional information. Safety assessment of hydroxypropyl methylcellulose. Hydroxypropyl methyl cellulose phthalate methods for cleaning up wear protective clothing as described in section 8 of this safety data sheet.
The top countries of supplier is china, from which the percentage of hydroxypropyl cellulose price supply is 100% respectively. Sigmaaldrich offers a number of hydroxypropyl cellulose products. Material safety data sheet hydroxypropyl methyl cellulose hpmc 1 company and product identification. Safety assessment of hydroxypropyl methylcellulose as a food ingredient article in food and chemical toxicology 4512. Walocel mw 40000 pfv 50 methyl hydroxyethyl cellulose company identification the dow chemical company 2030 willard h.
Material safety data sheet the dow chemical company. Material safety data sheet hydroxypropyl cellulose sc252897 hazard alert code key. Its chemically modified so that when it is heated, it becomes flexible but not flowable. If irritation occurs or persists, get medical attention. Procedure transfer about 65 mg of hydroxypropyl cellulose, previously dried at 105 for 1 hour and accurately weighed, into the reaction flask. Hydroxypropyl cellulose 9004642 not listed dibasic calcium phosphate, dihydrate usp 7789777 not listed sodium starch glycolate 9063381 not listed. It combines solubility in aqueous and polar organic solvents, thermoplasticity, and surface activity with the thickening and stabilizing properties of other watersoluble cellulose. Other companies are charging thousands of dollars to set up. Hydroxypropyl cellulose acts to stabilize and thicken the precorneal tear film and prolong the tear film breakup time which is usually accelerated in patients with dry eye states. Hydroxypropyl methyl 9004324 9099 cellulose sodium chloride nacl 7647145 1 10 3 hazards indentification emergency overview offwhite powder. Our msds database is an easy to use, do it yourself tool, and best of all.
Difference between methyl cellulose mc and hydroxypropyl methyl cellulose hpmc 1. If you use hydroxypropyl cellulose on a regular basis, use a missed dose as soon as you think about it. Gonak hypromellose ophthalmic demulcent solution, 2. Collect powder using special dust vacuum cleaner with particle filter or carefully sweep into suitable waste disposal containers and seal securely.
Use dry chemical powder, water spray fog, foam or co2 unsuitable extinguishing media. Methocel k100m premium hydroxypropyl methylcellulose msds. Description, hydroxypropyl cellulose hpc is a derivative of cellulose being. Hydroxypropyl cellulose 9004642 buy and find out price and availability, msds, properties of tcis high quality specialty chemicals. One study in rats indicated there was an increase in fetal resorptions, gross and skeletal malformations after a 1 and 4% hpmc i.
Cellulose derivatives such as methylcellulose, hydroxypropyl cellulose, and carboxymethyl cellulose cmc are being extensively used to produce films due to their suitable properties sanlaead et al. Feb 28, 2014 the hydroxypropyl cellulose monograph will be incorporated into and become official with the second supplement to usp 37nf 32. Use hydroxypropyl cellulose as ordered by your doctor. The introduction of polymers into a chiral nematic cellulose nanocrystal cnc matrix allows for the tuning of optical and mechanical properties, enabling the development of responsive photonic materials.
Cellulose alone or in combination with other matrixes has been employed in food packaging applications. Hydroxypropyl methylcellulose is produced by treating heated cellulose fibers with a caustic solution which in turn is reacted with methyl chloride and propylene oxide yielding the propylmethyl ether of cellulose. Chemistry of methocel cellulose ethers a technical. Hydroxypropyl methylcellulose hpmc belongs to the group of cellulose ethers in which hydroxyl groups have been substituted with one or more of the three hydroxyl groups present in the cellulose ring fig. However, hydroxypropyl cellulose a similar cellulose derivative has been tested in both rats and rabbits. Sds of hydroxypropyl cellulose, safety data sheets, cas 9004642. Suitability requirements transfer 1ml of this solution to a glass plate, and al resolution. The hydroxyethyl cellulose monograph will be incorporated into usp nf and become official from aug.
Sds of hydroxypropyl cellulose, safety data sheets, cas. Pfizer inc believes that the information contained in this material safety data sheet is accurate, and while it is provided in good faith, it. See actual entry in rtecs for complete information. Klucel hydroxypropylcellulose hpc is a nonionic watersoluble cellulose ether with a remarkable combination of properties. The common name for this form of the additive is low substituted hydroxypropyl cellulose. Hpmc has not been evaluated in any standard reproduction test. Hydroxypropyl cellulose hpc is a derivative of cellulose with both water solubility and organic solubility. Hydroxypropylcellulose hpc in aqueous solution interacts with sodium dodecylsulfate sds to give micellelike sds clusters bound to the.
Klucel hydrooxypropylcellulose cs grade is a nonionic, watersoluble cellulose ether with a versatile combination of properties in personal care applications. Should you have any questions about the hydroxyethyl cellulose monograph, please contact dr. Do not use 2 doses at the same time or extra doses. Methocel cellulose ethers belong to an extensive family of white to offwhite, watersoluble methylcellulose and hydroxypropyl methylcellulose polymers that bind, retain water, thicken, form films, lubricate, and much more. Extreme high moderate low section 1 chemical product and company identification product name hydroxypropyl cellulose statement of hazardous nature not considered a hazardous substance according to osha 29 cfr 1910. Safety data sheet 2 hydroxypropyl acrylate date prepared. Safety data sheet hydroxypropylmethyl cellulose phthalate.
Commission regulation eu no 2015830 of 28 may 2015. It is used as an excipient, and topical ophthalmic protectant and lubricant. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Some typical molecular weight values are given in table i. Hydroxypropyl cellulose 9004642 not listed not listed opadry white not assigned not listed not listed polysorbate 80 9005656 not listed not listed additional information. Hydroxypropyl cellulose 9004642 not listed not listed additional information. American polymer standards corporation safety data sheet. How is this medicine hydroxypropyl cellulose best taken.
Hydroxypropyl cellulose not listed as a carcinogen by acgih, iarc, ntp, or ca prop 65. Hydroxypropyl cellulose 9004642 not listed not listed not listed polysorbate 80 9005656 not listed not listed not listed. Extreme high moderate low santa cruz biotechnology. The fibrous reaction product is purified and ground to a fine, uniform powder. This product has a strong bad smell and irritation. Apr 01, 2019 2 a cellulose ether containing propylene glycol groups attached by an ether linkage having a hydroxypropoxy oc3h6oh content of 5 to 16 percent weight in weight ww on an anhydrous basis, i.
Hpc is an ether of cellulose in which some of the hydroxyl groups in the repeating glucose units have been hydroxypropylated forming och 2 chohch 3 groups using propylene oxide. Hydroxypropyl cellulose cellulose, 2 hydroxypropyl ether is a derivative of cellulose with both water solubility and organic solubility. Immediately flush eyes with water for at least 15 minutes. Safety data sheet northwest missouri state university.